Just a small resume of those interesting and so promising articles to which I am refering at the end of my posting.
"Just about a year after scientists from University of Winsconsin-Madison showed that skin cells could produce stem cells, more promising results come out now from their recent study, published online on February.
In their study, they used induced pluripotent stem cells (iPS cells), in order to characterize their cardiac differentiation potential, compared to human embryonic stem (ES) cells. The iPS cells were generated by the viral insertion of four transgenes (OCT4, SOX2, NANOG and LIN28) into human skin fibroblasts.
They showed that iPS cells can actually differentiate into functional cardiomyocytes, which apart from opening new pathways in the field of cardiovascular research, is also very promising for cardiac repair, as they could be used as an autologus cell source.
Furthermore, according to their previous study published on Nature, they showed that iPS cells generated from skin fibroblasts from a child with spinal muscular atrophy, maintained the disease genotype and they could serve as study models for disease mechanisms and drug development"
Functional cardiomyocytes derived from human induced pluripotent stem cells. Circ Res 2009 Feb 12
Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 2009 Jan 15;457(7227):277-80
University of Wisconsin-Madison (2009, February 13). Stem Cells From Skin Cells Can Make Beating Heart Muscle Cells. ScienceDaily. Retrieved February 14, 2009
"Just about a year after scientists from University of Winsconsin-Madison showed that skin cells could produce stem cells, more promising results come out now from their recent study, published online on February.
In their study, they used induced pluripotent stem cells (iPS cells), in order to characterize their cardiac differentiation potential, compared to human embryonic stem (ES) cells. The iPS cells were generated by the viral insertion of four transgenes (OCT4, SOX2, NANOG and LIN28) into human skin fibroblasts.
They showed that iPS cells can actually differentiate into functional cardiomyocytes, which apart from opening new pathways in the field of cardiovascular research, is also very promising for cardiac repair, as they could be used as an autologus cell source.
Furthermore, according to their previous study published on Nature, they showed that iPS cells generated from skin fibroblasts from a child with spinal muscular atrophy, maintained the disease genotype and they could serve as study models for disease mechanisms and drug development"
Functional cardiomyocytes derived from human induced pluripotent stem cells. Circ Res 2009 Feb 12
Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 2009 Jan 15;457(7227):277-80
University of Wisconsin-Madison (2009, February 13). Stem Cells From Skin Cells Can Make Beating Heart Muscle Cells. ScienceDaily. Retrieved February 14, 2009
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